GENETIC MODIFIERS OF STREPTOMYCIN RESISTANCE IN PNEUMOCOCCUS
نویسندگان
چکیده
منابع مشابه
Genetic modifiers of streptomycin resistance in Pneumococcus.
Bryan, Betty E. (University of Rochester, Rochester, N. Y.). Genetic modifiers of streptomycin resistance in pneumococcus. J. Bacteriol. 82:461-470. 1961.-Streptomycin-resistant mutants arising spontaneously in pneumococcus vary widely with respect to the maximal concentrations of streptomycin which they resist. A small random sample of these mutations tested for linkage are allelic or closely ...
متن کاملThe mapping of genetic loci affecting streptomycin resistance in Pneumococcus.
HE term “complex locus” implies a series of closely linked genetic deterTminants all of which produce similar or identical modifications in the phenotype of an organism. Much of the experimental work to be described is concerned with a series of this type conferring streptomycin resistance in Pneumococcus. BRYAN (1 961 ) has isolated spontaneous streptomycin-resistant mutants of Pneumococcus wh...
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Transformation of resistance to antibiotics was observed in Diplococcus pneumoniae by Hotchkiss (1951, 1952a, 1952b) and in Haemophilus influenzae by Alexander and Leidy (1953) and Alexander et al. (1954). In all these species only certain strains were capable of being transformed. The ability to be transformed has been termed competence; refractory strains are not competent. Austrian (1952) ha...
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Cell-free extracts of Streptomyces bikiniensis contain an adenosine 5'-triphosphate-dependent kinase which inactivates streptomycin (Sm) and dihydrostreptomycin by phosphorylation. The products have been identified as streptomycin 6-phosphate and dihydrostreptomycin 6-phosphate. Activity was not present in logarithmic-phase cells, which were susceptible to 25 mug of Sm per ml. In stationary-pha...
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Insulin resistance can result from genetic interactions among susceptibility alleles. To identify genetic loci predisposing to insulin resistance, we used crosses between different strains of mice with a targeted null allele of the insulin receptor gene. On the genetic background of B6 mice, the insulin receptor gene mutation causes mild hyperinsulinemia. In contrast, on the genetic background ...
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ژورنال
عنوان ژورنال: Journal of Bacteriology
سال: 1961
ISSN: 0021-9193,1098-5530
DOI: 10.1128/jb.82.4.461-470.1961